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Week 4 of development
◦ABOUT DAYS 22 TO 23: embryo is almost straight or slightly curved, and somites create conspicuous surface elevations. The neural tube is closed opposite the somites but is open at its caudal and rostral neuropores
◦ABOUT DAY 24: the first (mandibular) and second (hyoid) branchial arches become distinct
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◦ABOUT DAY 26: 3 pairs of branchial arches are seen and the rostral neuropore closes
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- Transverse folding causes a narrowing of the connection between yolk sac and embryo
- The arm buds are now recognizable as small swellings on the body wall’s ventral surface
- The otic pits, the primordia for the inner ears, are clearly seen
◦ABOUT DAY 28 (END OF WEEK 4): the fourth pair of branchial arches and the leg buds are seen
- The lens placodes (ectodermal thickenings) represent the future lenses on the side of the head
Week 5 of development
There are fewer body form changes this week
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- The face contacts the heart prominence
- The second (hyoid) branchial arch overgrows arches 3 and 4 to form an ectodermal depression, the cervical sinus
- The forelimbs show some regional differentiation as the hand plates develop
Week 6 of development
1. LIMB BUDS, especially the forelimbs, show regional differentiation. Hind limbs develop later
- Elbow and wrist areas are identifiable
- Paddle-shaped hand plates develop digital ridges, the finger rays, for future fingers
2. SOME SMALL SWELLINGS appear around the groove between the first branchial arches. The groove becomes the external auditory meatus, the swellings the ear auricle
3. THE EYE becomes obvious due to appearance of retinal pigment
4. THE HEAD appears larger relative to the trunk and bends even farther over the heart prominence
- Bending is due to the cervical flexure as a result of bending of the brain in the cervical region
- The trunk and neck begin to straighten out
5. SOMITES are visible in the lumbosacral region by the middle of this week
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